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Clinical evaluation of the effect of tamsulosin hydrochloride and cernitin pollen extract on urinary disturbance associated with benign prostatic hyperplasia in a multicentered study


Aoki A, Naito K, Hashimoto O, Yamaguchi M, Hara Y, Baba Y, Wada T, Joko K, Nagao K, Yamakawa G, Suyama K, Nagata K, Matsuyama H, Hirao H, Shimizu Y, Hironaka H, Isoyama R, Takemoto M, Tuchida M, Shiraishi K, Kato M, Kamiryo Y, Harada H, Otsuka T, Mitsui H, Nasu T, Hayashida S, Jojima K, Sacho T, Koshido Y, Harada N.


Department of Urology, Yamaguchi University School of Medicine.


We evaluated the clinical efficacy and safety of tamsulosin hydrochloride and cernitin pollen extract in 243 patients with urinary disturbance associated with benign prostatic hyperplasia. They were assigned randomly to 3 groups, oral tamsulosin hydrochloride, cernitin pollen extract and their combination were
administered for 12 weeks. The international prostate symptom score, post-voided residual urine and uroflowmetrogram were obtained before and after treatment. The international prostate symptom score improved in each group and then the maximum flow rate and average flow rate also increased significantly in the tamsulosin hydrochloride-administered groups. In conclusion, the administration of only tamsulosin hydrochloride and the combination of tamsulosin hydrochloride and cernitin pollen extract seemed more effective then the administration of only cernitin pollen extract in the treatment of urinary disturbance associated with benign prostatic hyperplasia.


Publication Types:
Clinical Trial
Multicenter Study
Randomized Controlled Trial


PMID: 12094707 [PubMed - indexed for MEDLINE]

 

 

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